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The main objective of Cardiac Remodeling: Molecular Mechanisms is to summarize the major research advances in molecular, biochemical and translational aspects of cardiac remodeling over the last 2 to 3 decades under one cover and touch on future directions. It provides a high profile and valuable publication resource on molecular mechanisms of cardiac remodeling for both the present and future generations of researchers, teachers, students and trainees.This bookshould stimulate future translational research targeted towards discovery and development for preventing, limiting and reversing bad remodeling over the next few decades, with the ultimate goal of preventing progression to systolic and/or diastolic heart failure. The chapters suggest potential novel strategies that should receive attention for translating basic research knowledge to application in patients at the bedside.
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Cardiovascular disease is the major cause of morbidity and mortality worldwide. While the past 40 years have brought major progress in cardiac valve repair and replacement, there remain large patient populations that do not receive such therapies. This, in turn, implies a great need for future basic, applied, and clinical research and, ultimately, therapeutic developments. Heart Valves is a state-of-the-art handbook dedicated to: 1) cardiac valve anatomy, 2) models for testing and research methods; 3) clinical trials; and 4) clinical needs and applications.
Androgens and androgen receptors (AR) play critical roles in the development and progression of prostate cancer, the most frequently diagnosed cancer and second leading cause of cancer death in US males. AR is an androgen-dependent DNA-binding transcription factor that regulates the expression of androgen-responsive genes. Identification and characterization of androgen-responsive genes provide insights into the cellular mechanisms of androgen action and may lead to new approaches in diagnosis, prognosis, prevention and/or treatment of prostate cancer. This volumeprovides critical information from well respected experts in the field. Some of the exciting topics includethenewunderstanding ofmechanisms underlining the regulation of androgen-responsive gene expression, and functions of various androgen-responsive genes in biological processes essential in carcinogenesis including cell growth, angiogenesis, and epithelial-to-mesenchyme transition (EMT). Other important aspects addressed are the current and potential clinic applications of knowledge on androgen-responsive gene regulation and function. This book is intended for researchers, scientists, faculty, and advanced graduate students with aninterest in androgen action and prostate cancer.?
This handbook, written in a clear and precise style, describes the principles of positron emission tomography (PET) and provides detailed information on its application in clinical practice. The first part of the book explains the physical and biochemical basis for PET and covers such topics as instrumentation, image reconstruction, and the production and diagnostic properties of radiopharmaceuticals. The focus then turns to the use of PET in clinical practice, including its role in hybrid imaging (PET-CT). A wide range of oncological applications in different body systems and organs are discussed, and uses of PET in cardiology, neurology, and psychiatry are also addressed. Characteristic findings are described and illustrated by numerous images, many of them in color. This book will be of value not only for nuclear medicine physicians and radiologists but also for oncologists, surgeons, cardiologists, neurologists, psychiatrists, and residents with an interest in molecular imaging.
Diffusion Tensor Imaging (DTI) is a variation of diffusion-weighed imaging. Particularly in the neurosciences, this technique has gained tremendous momentum in the past decade, both from a technical point of view as well as in its applications. DTI is mainly used in neurological diagnosis and psychiatric and neurologic research, e.g. in order to locate brain tumors and depict their invasivity.DTI offers a unique in-vivo insight into the three-dimensional structure of the human central nervous system. While easy interpretation and evaluation is often hampered by the complexity of both the technique and neuroanatomy, this atlas helps you recognize every one of the important structures rapidly and unambiguously.In the introduction, this atlas provides a concise outline of the evolution of diffusion imaging and describes its potential applications. In the core part of the atlas, the neuroanatomically important structures are clearly labeled both on DTI-derived color maps and conventional MRI. Complex fiber architecture is illustrated schematically and described concisely in textboxes directly on the relevant page. In the final part of the atlas, a straightforward, step-by-step approach for the three-dimensional reconstruction of the most prominent fiber structures is given, and potential pitfalls are indicated.The atlas aims at neuroscientists, neuroanatomists, neurologists, psychiatrists, clinical psychologists, physicists, and computer scientists. For advanced users, the atlas may serve as a reference work, while students and scientists are thoroughly introduced into DTI.
The combination of molecular biology, engineering and bioinformatics has revolutionized our understanding of cancer revealing a tight correlation of the molecular characteristics of the primary tumor in terms of gene expression, structural alterations of the genome, epigenetics and mutations with its propensity to metastasize and to respond to therapy. It is not just one or a few genes, it is the complex alteration of the genome that determines cancer development and progression. Future management of cancer patients will therefore rely on thorough molecular analyses of each single case. Through this book, students, researchers and oncologists will obtain a comprehensive picture of what the first ten years of cancer genomics have revealed. Experts in the field describe, cancer by cancer, the progress made and its implications for diagnosis, prognosis and treatment of cancer. The deep impact on the clinics and the challenge for future translational research become evident.
The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications.
A good number of misconceptions are currently circulating on the effects of non-ionizing radiations on our health, which can lead to an oversimplification of the issue, to potentially dangerous assumptions or to misleading data analysis. Health effects may be exaggerated, or on the contrary underplayed. The authors of this work (doctors, engineers and researchers) have endeavored to supply validated and easily understandable scientific information on the electromagnetic fields and their biological and health effects. After a general review of the physics of the waves and a presentation of non-ionizing radiations, the authors review the main emission sources encountered in our daily environment. They summarize simply but as accurately as possible the current knowledge on their biological effects.The safety limits recommended by international organizations are presented for the different frequency ranges. This book is intended for doctors, teachers, scientists, students, policy makers and anyone else interested in a deeper understanding of the health effects of electromagnetic fields. Intended to serve a broad readership, everyone will approach it according to their respective level of curiosity and knowledge. It is neither an exhaustive inventory of all the studies made to date, nor a survey text focusing only on some chosen studies. Nor is the objective to present all the sources of non-ionizing radiations. Interested readers will be given the opportunity to broaden their knowledge, also by consulting the selected bibliography presented by the authors at the end of each chapter.
After the successful introduction of acupuncture to the West, recent advances in analytical methods in chemistry, molecular biology and systems biology - especially the development of the omic technologies - have again brought Chinese drugs into the focus of research on Traditional Chinese Medicine (TCM). With more than 1000 publications on the chemistry, molecular biology and pharmacology of TCM drugs in international journals over the last 10 years, Chinese drugs are gaining increasingly reputation and impact. These data offer great opportunities for the development of new pharmaceuticals for various clinical applications. International scientists have compiled relevant and trend setting research results in this book. Topics range from the latest methods of quality and safety assurance by chemical and genetic fingerprints to the development of new pharmaceuticals for a future evidence-based therapy e.g. for cancer, cardiovascular, inflammatory or infectious diseases as well as to recent experimental results on multitarget and synergy research for the preparation of multi-extract-pharmaceuticals from TCM.