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Featuring a comprehensive approach to sample size determination for general statistical use, this book uniquely blends applications from a variety of fields including statistics, biostatistics, the health sciences, and engineering. Topical coverage includes: hypothesis testing concepts and issues; confidence intervals; methods of determining sample sizes; means and variances; proportions and rates; regression methods and correlation; experimental designs; clinical trials; quality improvement; survival analysis and reliability; and nonparametric methods.
THOMAS P. RYAN, PhD, teaches online advanced statistics courses for Northwestern University and The Institute for Statistics Education in sample size determination, design of experiments, engineering statistics, and regression analysis.
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The phylontogenic theory proposes an original understanding of nose, sinus and midface formation and development by looking back in evolution for the first traces of the olfactory organ and then tracing its successive phyletic transformations to become part of the respiratory apparatus and finally the central point of human facial anatomy. Von Baer's, Darwin's, Haeckel's, Garstang's, Gould's and Buss' explorations of parallels between phylogeny and ontogeny help to trace the nose and midface story. The paradigm of existing parallels between ontogeny and phylogeny proves useful both in seeking to understand the holoprosencephalic spectrum of facial malformations (which represent radically different pathways of facial development after the life's tape has been started to run again) and in formulating hypotheses on chordate to vertebrate evolution. The phylontogenic theory leads to new medical hypotheses on nose and sinus diseases and opens the field of evolution and development-based medicine.
This brand new title in the market-leading at a Glance series brings together fundamental information on cancer biology and treatment to provide a holistic understanding of oncology. It explores both relevant scientific content and key human issues, including communication and palliative care.Oncology at a Glance:• Provides an accessible overview of the scientific foundation of cancer medicine• Covers the common cancers as well as key information on presentation and approaches to investigation and management• Includes young adult oncology, the multidisciplinary team, clinical trials in oncology, approach to treatment and response assessment, management of nausea, and end-of-life care• Was developed with students for students, to ensure it contains exactly what students need to know
Oncology at a Glance is an ideal guide for medical students and foundation-year doctors as well as any other healthcare professionals looking to consolidate their knowledge of oncology.
Many diseases earlier considered to be incurable are now being treated with modern innovations involving fetal tissue transplants and stem cells derived from fetal tissues. Fetal tissues are the richest source of fetal stem cells as well as other varying states of differentiated cells and support or stromal cells. The activity of such stem cells is at their peak provided they are given the correct niche.Stem cells, as we know, are immortal cells with the capacity to regenerate into any kind of differentiated cell as per niche-guidance. As such, fetal tissues have the potential capacity to mend, regenerate and repair damaged cells or tissues in adults, when directly transplanted to the site of injury, or even when transplanted in some other site, because it may have a homing capacity to migrate to the site of the specific injured organ.This is a new area of translational research and needs to be highlighted because of its immense potential. This book will bring together the new work of prominent medical scientists and clinicians who are conducting pioneering research in human fetal tissue transplantation. This will include direct transplant of healthy fetal tissue into mature patients as well as in hosts with genetic diseases.Transplant techniques, donor-host interaction, cell and tissue storage, ethical and legal issues, are some of the many matters which the book will deal with.
This book can be used to provide insight into this important application of biophysics for those who are planning a career in protein therapeutic development, and for those outside this area who are interested in understanding it better. The initial chapters describe the underlying theory, and strengths and weaknesses of the different techniques commonly used during therapeutic development. The majority of the chapters discuss the applications of these techniques, including case studies, across the product lifecycle from early discovery, where the focus is on identifying targets, and screening for potential drug product candidates, through expression and purification, large scale production, formulation development, lot-to-lot comparability studies, and commercial support including investigations.
Bone Sarcoma is a succinct volume within the M.D. Anderson Cancer Care Series that summarizes the key elements of different specialties as they pertain to these cancers. It is a vital resource for physicians working with these uncommon yet fascinating bone sarcomas and uses a multidisciplinary team approach that is essential to maximizing a patient's chances of a successful outcome. Written for physicians who have an interest in how the entire treatment process works and how their efforts are intertwined with those of their colleagues, Bone Sarcoma covers topics such as diagnostic techniques, treatment modalities, reconstruction and function, and a more globally oriented chapter geared towards algorithms for perioperative management and follow-up of patients.Designed for the busy practitioner, the esteemed M.D. Anderson Cancer Care Series offers an in-depth view of the current standard of care at M. D. Anderson, without extensive literature review or discussion of approaches not yet incorporated into routine clinical practice. Each chapter ends with an up-to-date list of suggested readings and a list of key practice points highlighting the most important principles presented. These books offer a clear picture of how M. D. Anderson is successfully treating patients today.
The cases presented in this book will guide the reader through the process of making a diagnosis based on logical thinking. The book provides a wealth of knowledge regarding diagnostic approaches and pearls of wisdom. In addition to unusual presentations of common diseases, it includes discussions about rare diseases, complex cases, surprising diagnoses, therapeutic challenges and other important features.Becoming acquainted with such unusual cases will provide the dermatologist with increased knowledge, a wider perspective, and innovative techniques that can be used to solve diagnostic dilemmas. Readers will improve their way of thinking and data analysis, and will be able to improve differential diagnoses. This book provides the unique feature of a strategic way of thinking while discussing each case, in order to reach a diagnosis. The text includes comparisons of each case to other similar cases, pointing out the distinguishing features of conditions under consideration.
The articles in this volume cover the various options of the optimal management of brain tumors, vascular lesions, and functional disorders. They provide a good balance between microneurosurgery and radiosurgery, presenting also alternative surgical and radiosurgical treatment options with discussions on their advantages and disadvantages. The presentation of multiple treatment methods will help to provide better service to patients. Some papers, specifically highlighting alternative treatment options, are accompanied by editorials prepared by recognized experts in the field. Additional emphasis is put on importance of the advanced neuroimaging techniques for radiosurgical treatment planning and subsequent follow-up.
After the successful introduction of acupuncture to the West, recent advances in analytical methods in chemistry, molecular biology and systems biology - especially the development of the omic technologies - have again brought Chinese drugs into the focus of research on Traditional Chinese Medicine (TCM). With more than 1000 publications on the chemistry, molecular biology and pharmacology of TCM drugs in international journals over the last 10 years, Chinese drugs are gaining increasingly reputation and impact. These data offer great opportunities for the development of new pharmaceuticals for various clinical applications. International scientists have compiled relevant and trend setting research results in this book. Topics range from the latest methods of quality and safety assurance by chemical and genetic fingerprints to the development of new pharmaceuticals for a future evidence-based therapy e.g. for cancer, cardiovascular, inflammatory or infectious diseases as well as to recent experimental results on multitarget and synergy research for the preparation of multi-extract-pharmaceuticals from TCM.
Edited by master clinician-experts appointed by the American Academy of Pain Medicine, this is a state-of-the-art multidisciplinary textbook covering medical, interventional, and integrative approaches to the treatment and management of pain. It is designed as a practical and comprehensive primary reference for busy physicians and is also an up-to-date resource for preparing for certification examinations in pain medicine.Â· Written and edited by world-class authoritiesÂ· Key Points preview contents of each chapterÂ· Leading edge medical topics, such as monitoring opioid use and abuse, and the emerging role of cannabinoids in pain treatmentÂ· Expert guidance on full range of interventional techniquesÂ· Clinical anatomy and physiology for the interventionistÂ· Behavioral dimensions of the experience and management of painÂ· Integrative approaches for treating the whole person Â· Legal issues, such as failure to treat painÂ· First-hand patient accounts